Ruthenium-Catalyzed Asymmetric Monohydrogenation of meso-Cyclic Imides

doi:10.1055/s-0030-1258900

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Synfacts 2010(12): 1396-1396
DOI: 10.1055/s-0030-1258900

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Ruthenium-Catalyzed Asymmetric Monohydrogenation of meso-Cyclic Imides

Contributor(s): Hisashi Yamamoto, Zhi Li
S. Takebayashi, J. M. John, S. H. Bergens*
University of Alberta, Edmonton, Canada

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Publication History

Publication Date:
22 November 2010 (online)

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Significance

This paper features the first asymmetric monohydrogenation of meso-cyclic imides. A variety of cyclic imides were selectively hydrogenated on one of the two carbonyls to generate hydroxyl lactams in high yields and stereoselectivities.